Pneumococcal Conjugate Vaccine


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Infection with Streptococcus pneumoniae bacteria can cause serious illness and death. Invasive pneumococcal disease is responsible for about 200 deaths each year among children under 5 years old. It is the leading cause of bacterial meningitis in the United States. (Meningitis is an infection of the covering of the brain).

Pneumococcal infection causes severe disease in children under five years old. Before a vaccine was available, each year pneumococcal infection caused:

  • Over 700 cases of meningitis
  • 13,000 blood infections
  • About 5 million ear infections

It can also lead to other health problems, including:

  • Pneumonia
  • Deafness
  • Brain damage

Children under 2 years old are at highest risk for serious disease.

Pneumococcus bacteria are spread from person to person through close contact.

Pneumococcal infections can be hard to treat because the bacteria have become resistant to some of the drugs that have been used to treat them. This makes prevention of pneumococcal infections even more important.

Pneumococcal conjugate vaccine can help prevent serious pneumococcal disease, such as meningitis and blood infections. It can also prevent some ear infections. But ear infections have many causes, and pneumococcal vaccine is effective against only some of them.

Pneumococcal conjugate vaccine

Pneumococcal conjugate vaccine is approved for infants and toddlers. Children who are vaccinated when they are infants will be protected when they are at greatest risk for serious disease.

Some older children and adults may get a different vaccine called pneumococcal polysaccharide vaccine. There is a separate Vaccine Information Statement for people getting this vaccine.

Who should get the vaccine and when?

Children Under 2 Years of Age

The routine schedule for pneumococcal conjugate vaccine is 4 doses, one dose each at 2 months, 6 months, 4 months, and 12-15 months.

Children who weren’t vaccinated at these ages can still get the vaccine. The number of doses needed depends on the child’s age. Ask your health care provider for details.

Children Between 2 and 5 Years of Age

Pneumococcal conjugate vaccine is also recommended for children between 2 and 5 years old who have not already gotten the vaccine and are at high risk of serious pneumococcal disease. This includes children who:

  • have sickle cell disease
  • have a damaged spleen or no spleen
  • have HIV/AIDS
  • have other diseases that affect the immune system, such as diabetes, cancer, or liver disease
  • take medications that affect the immune system, such as chemotherapy or steroids
  • have chronic heart or lung disease

The vaccine should be considered for all other children less than 5 years, especially those at higher risk of serious pneumococcal disease. This includes children who:

  • are under 3 years of age
  • are of Alaska Native, American Indian or African American descent
  • attend group day care

The number of doses needed depends on the child’s age. Ask your health care provider for more details. Pneumococcal conjugate vaccine may be given at the same time as other vaccines.

Some children should not get pneumococcal conjugate vaccine, or should wait.

Children should not get pneumococcal conjugate vaccine if they had a serious (life-threatening) allergic reaction to a previous dose of this vaccine, or have a severe allergy to a vaccine component. Tell your health-care provider if your child has ever had a severe reaction to any vaccine, or has any severe allergies.

Children with minor illnesses, such as a cold, may be vaccinated. But children who are moderately or severely ill should usually wait until they recover before getting the vaccine.

What are the risks from pneumococcal conjugate vaccine?

In studies (nearly 60,000 doses), pneumococcal conjugate vaccine was associated with only mild reactions:

  • Up to about 1 infant out of 4 had redness, tenderness, or swelling where the shot was given.
  • Up to about 1 out of 3 had a fever of over 100.4 degrees Fahrenheit, and up to about 1 in 50 had a higher fever (over 102.2 degrees Fahrenheit)
  • Some children also became fussy or drowsy, or had a loss of appetite.

So far, no serious reactions have been associated with this vaccine. However, a vaccine, like any medicine, could cause serious problems, such as a severe allergic reaction. The risk of this vaccine causing serious harm, or death, is extremely small.

What if there is a severe or moderate reaction?

What should I look for?

Look for any unusual condition, such as a serious allergic reaction, high fever, or unusual behavior.
Serious allergic reactions are extremely rare with any vaccine. If one were to occur, it would most likely be within a few minutes to a few hours after the shot. Signs can include:

  • difficulty breathing
  • hoarseness or wheezing
  • swelling of the throat
  • fast heart beat
  • weakness
  • dizziness
  • hives
  • paleness

What should I do?

  • Call a doctor, or get the child to a doctor right away.
  • Tell your doctor what happened, the date and time it happened, and when the vaccination was given.
  • Ask your doctor, nurse, or health department to report the reaction by filing a Vaccine Adverse Event Reporting System form.

Or you can file this report through the VAERS web site at www.vaers.org or by calling: 1-800-822-7967  VAERS does not provide medical advice.

The National Vaccine Injury Compensation Program

In the rare event that you or your child has a serious reaction to a vaccine, a federal program has been created to help pay for the care of those who have been harmed. For details about the National Vaccine Injury Compensation Program, call: 1-800-338-2382, or visit them online.

What is needed before Receiving the Pneumococcal Conjugate Vaccine?

On the day of your child's appointment, you will be asked to read information from the Centers for Disease Control and Prevention (CDC) regarding this vaccination. Information from that statement has been reproduced in this article.

  • To review the Vaccine Information Statement prior to your appointment, click here.
  • To view a full listing of the Vaccine Information Statements available through the CDC, click here.

Click here for more information on Pneumococcal Conjugate vaccine

This Vaccine Information Statement courtesy of:
U.S. Department of Health and Human Services
Centers for Disease Control and Prevention
National Immunization Program

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